Risk factors for chronic kidney disease in a family doctor's office in East Havana

Authors

  • Pedro Javier Machural de la Torre Universidad de Ciencias Médicas de La Habana, Facultad de Ciencias Médicas "Calixto García", Hospital Universitario "General Calixto García". La Habana, Cuba. https://orcid.org/0009-0007-7608-4182
  • Eisy Cabrera Vazquez Universidad de Ciencias Médicas de La Habana, Facultad de Ciencias Médicas "Calixto García", Hospital Universitario "General Calixto García". La Habana, Cuba. https://orcid.org/0009-0007-4360-0806

Keywords:

Albuminuria; chronic kidney disease; risk factors

Abstract

Introduction: Chronic kidney disease is described by nephrologists as the silent epidemic of the 21st century.
Objective: To determine the epidemiological factors associated with the development and progression of chronic kidney disease in a community.
Methods: An observational, descriptive, prospective study was conducted on 80 patients with chronic kidney disease in a doctor´s office in East Havana over one year. Risk factors for this disease were identified, and sociodemographic variables related to these factors were used.
Results: Females and black individuals predominated. The 18 - 30 and 31- 40 age groups were the least representative. Hypertension, smoking, and proteinuria were predominant in males; urinary tract obstructions were more frequent in males, and infections in females. Proteinuria and smoking predominated in those over 41 years of age and in advanced stages of kidney disease. Hypertension, diabetes mellitus, and obesity were present in most patients with end-stage renal disease.
Conclusions: It was demonstrated that hypertension, diabetes mellitus, and obesity were the most frequent diseases in chronic kidney patients. Urinary tract obstruction and infection, although not as frequent, did differ according to sex and age group. The most relevant finding was the high frequency of albuminuria and smoking, factors that were not identified in any study conducted in this community.

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References

1. Organización Mundial de la Salud (OMS) Chronic kidney disease (CKD). Geneva: World Health organization. 2023. [access: 14/06/2025]. Available from: https://www.who.int/news-room/fact-sheets/detail/kidney-disease

2. Ministerio de Salud Pública. Dirección de Registros Médicos y Estadísticas de Salud. Anuario estadístico de salud 2024 [Internet]. La Habana: Ministerio de Salud Pública; 2024. [acceso: 14/06/2025]. Disponible en: http://files.sld.cu/dne/files/2025/09/AES-2024-para-sitio-3.pdf

3. Organización Panamericana de Salud. Enfermedades no transmisibles en Cuba. Washington DC: OPS; 2023. [acceso: 24/03/2025]. Disponible en: https://www.paho.org/sites/default/files/2023-05/enfremedadesnotrasmisiblescuba.pdf

4. Guzman López A, Varona morales J, Zabalia Perez RJ. Factores de riesgo de progresión de la enfermedad renal crónica. RevMed Panamá. 2024;44(1):46-58. [acceso: 10/01/2026]. Disponible en: https://www.revcog.org/index.php/rmdp/artivle/view/2269

5. Hillege HL, Jannsen WMT, Bak AA, Diercks GFH, Grobbee DE, Crijns HJGM, et al. Indicator of Chronic Kidney Disease risk factors and morbidity. J Med. 2021;9(17):519-26. [access: 16/10/2025]. Avaliable from: https//academic.oup.com/ckj/article/16/11/1737/7143784

6. Scurt FG, Ganz MJ, Herzog C, Bose K, Mertens PR. Association of metabolic syndrome and chronic kidney disease. Obes Rev. 2024;25(1):e13649. [access: 14/01/2025]. Available from: https://pubmed.ncbi.nlm.nih.gov/37783465/

7. Inker LA, Eneanya ND, Coresh J. New creatinine and cystatin C- based equations to estimate GFR without race (CKD-EPI). N Engl J Med. 2021. [access: 14/07/2025]. Available from: https://www.nejm.org./doi/full/10.1056/NEJMoa2102953

8. Vaidya S, Ziyadeh FN, Silbiger S. Sex differences in the progression of kidney disease. Am J The lancet. 2013;382(9887):158-69. [access: 18/11/2025]. Avalilable from: https//doi.org/10.1016/s0272-6386(12)80112-8

9. Eckardt KU, Coresh J, Devuyst O. Evolving importance of sex differences in chronic kidney disease. Kidney Int. 2024;97(4):671-80. DOI: 10.1016/j.kint.2023.11.008.

10. O'Hare AM, Rodriguez RA,de Boer IH. Sex differences in chronic kidney disease: implications for disease progression and outcome. Curr Opin Nephrol Hypertens. 2023;32(12):19. DOI:10.1097/MNH.00000000000000785.

11. Mitch WEE; Sands JM, Joffe MM. Racial disparities in kidney disease: A population-based study. J Am Soc Nephrol. 2020;32(1):125-32. Available from: https://doi.org/10.1681/ASN.2019060652

12. Torrence G, Williams A, Martinez M. Genetic and environmental factors in racial disparities of chronic kidney disease. Nephrol Dial Transplant. 2021;36:1265-73. [access: 11/06/2026]. Avaliable from: https://pubmed.ncbi.nlm.nih.gov/34449991

13. Genovese G, Friedman DJ, Ross MD. APOL 1 risk variants and chronic kidney disease in Africa Americans. N Engl J Med. 2022;363(24):2406-214. [access: 11/04/2025]. Avaliable from: https://pmc.ncbi.nlm.nih.gov/articles/PMC29800843

14. Goyal K, Afzal M, Altamimi ASA, Babu MA, Ballal S, Kaur I, et al. Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic taget. Biogerontology. 2025;26(1):32. [access: 11/02/2025]. Avaliable from: https://pubmed.ncbi.nlm.nih.gov/39725742/

15. Davies D, Hallan S, Finlay M. The impact of aging on renal structure and function in chronic kidney disease. Kidney Int. 2023;104(1):53-60. [access: 1/06/2025]. Avaliable from: https://pubmed.ncbi.nlm.nih.gov/37031725/

16. Saran R, Robinson BM, Abbott KC. Prevalence of hypertension and its association with kidney disease: a global perspective. Kidney Int Suppl. 2020;97(4):717-25. DOI: 10.1016/j,kisu,2020,06,005

17. Eckardt KU, Coresh J, Devuyst O. Gender and hormonal factors in chonic kidney disease. Kidney Int. 2025;20(2):301-10. [access: 14/06/2025]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11835196/

18. Muntner P, Shimbo D, Carey RM. The Lancet.Prevalence of hypertension and its association with kidney disease: A global perspective. Lancet. 2020;396(10250):463-72. DOI:10.1016/S0140-6736(20)31390-3

19. Sharma A, Purnell JQ, Jacobsen SJ. Benign prostatic hyperplasia and the risk of chronic kidney disease. J.Urol. 2023;209(2):453-61. Available from: https://pubmed.ncbi.nlm.nih.gov/36687305/

20. Carter HB,Grossma HB, Yu S. Impact of benign prostatic hyperplasia on renal function and chronic kidney disease in older men: a cohort study. Lancet Urol. 2023;7(9):613-20. DOI:10.1016/S2468-113X

21. Hooton TM, Gupta K, Naber KG. Urinary tract infections in women: current concepts in the pathogenesis, diagnosis, and management. Lancet. 2020;396(10250):479-89. DOI:10.1016/S010-6736(20)31532-3

22. Boulware LE, McNally M,Deswal A. The epidemiology of chronic kidney disease and diabetic kidney disease in the elderly. Curr Diab Rep. 2024;14(12):548-54. [access: 11/12/2026]. Available from: https://pubmed.ncbi.nlm.nih.gov/29580576

23. National Kidney Foundation. Diabetic kidney disease (diabetic nephropathy). National Kidney Foundation [Internet]. 2023. [access: 10/08/2026]. Available from: https://www.kidney.org/subject/diabetic-kidney-disease

24. Wang J, Zhang H, Li H. Prevalence of proteinuria and its association with mortality in the elderly population: A global perspective. Lancet. 2023;401(10340):1234-42. [access: 10/08/2026]. Available from: https://link.springer.com/article/10.1186/S12882-021-02644-Z

25. Verhave JC, Gansevooort RT, Hillege HL, De Zeeuw D, De Jong PE. An elevated urinary albumin excretion predicts de novo development of renal function impairment in the general population. Kidney Int. 2024;66(2):662-68. [access: 10/08/2026]. Available from: https://www.sciencedirect.com/sciemcies/article/abs/pii/

26. Patel R, Smith B, Mehta M. Urinary tract infection in adolescents: prevalence and risk factor in the general population. Lancet Infect Dis. 2022;(10):1279-85. DOI:10.1016/S1473-3099(22)00415-2

27. Martin NL, Morales J, Hernández J. Prevalence of urinary tract infections in Young adults: A clinical review.Nephrol Dial Transplant. 2024;37(9):1692-8. [access: 10/08/2026]. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0196655324005510

28. Badura K, Janc J, Wasik J, Gnitecki S, Skwira S, Mlynarska E, et al. Anemia of chronic kidney disease-A narrative review of its pathophysiology, diagnosis, and management. Biomedicine. 2024;12(6):1191. [access: 10/08/2026]. Available from: https://www.mdpi.com/2227-9059/12/6/1191

29. National Kidney Foundation. Anemia in chronic kidney disease(CKD). 2026. [access: 10/08/2026]. Available from: https://www.niddk.nih.gov/health-information/kidney-disease/anemia

Published

2026-08-27

How to Cite

1.
Machural de la Torre PJ, Cabrera Vazquez E. Risk factors for chronic kidney disease in a family doctor’s office in East Havana. Arch Hosp Univ "Gen Calixto García” [Internet]. 2026 Aug. 27 [cited 2026 Aug. 28];14(2). Available from: https://revcalixto.sld.cu/index.php/ahcg/article/view/1666

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Section

Artículos de Investigación