Adverse reactions to Enalapril resulting from therapeutic interchangeability

Abstract

Introduction: Antihypertensive drugs are among the most imported, including enalapril. The number of patients with adverse reactions to the foreign-origin drug has increased in the municipality of Puerto Padre, Las Tunas province.
Objective: To identify the main adverse reactions in hypertensive patients treated with enalapril of foreign origin.
Methods: An observational, descriptive, and cross-sectional study was conducted from January to December 2024 at the medical office No. 11 in Puerto Padre, Las Tunas. The study population consisted of 33 patients who attended the consultation due to adverse reactions after consuming imported enalapril. Descriptive statistics were used for data processing.
Results: The male sex (n = 19; 57.57 %) and the ages between 45 - 54 years (n = 12; 36.36 %) predominated in the study. The intensity was mild in 23 patients (69.69 %), with the most frequent being rebound effect (n = 20; 60.60 %) in the first two days of treatment (n = 26; 78.78 %), with symptoms suggestive of hypertension such as headache (n = 29; 87.87 %).
Conclusions: The male sex predominated, and ages between 45 - 54 years. Most adverse reactions were mild, and rebound effect was notable in the first two days of treatment. Headache was the most representative symptom.